Side effects
DHEA appears to be very safe when taken in physiologic doses and with appropriate monitoring. Possible side effects include acne or increased hair growth when large doses are administered - these will resolve with reduction in dosage.
Because some DHEA can be converted into oestrogens, there is a theoretical concern regarding its use in postmenopausal women with a history of breast cancer. However, blood testing in postmenopausal women on DHEA replacement does not indicate any significant increase in oestrogen levels, and the cancer- protective effects of DHEA are documented.
DHEA may potentiate the action of thyroid hormones, and in some individuals a reduction in dosage (of the thyroid hormones) may therefore be necessary.
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